Ciclopirox inhibits Hepatitis B Virus secretion by blocking capsid assembly > REFERENCE LIBRARY

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[EZ-Cytox] Ciclopirox inhibits Hepatitis B Virus secretion by blocking capsid assembly

김상진
2020-01-08 16:01 3,955 1

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년도
2019
제품명
EZ-Cytox
학술지명
Nature communications

Chronic hepatitis B virus (HBV) infection can cause cirrhosis and hepatocellular carcinoma and is therefore a serious public health problem. Infected patients are currently treated with nucleoside/nucleotide analogs and interferon α, but this approach is not curative. Here, we screen 978 FDA-approved compounds for their ability to inhibit HBV replication in HBV-expressing HepG2.2.15 cells. We find that ciclopirox, a synthetic antifungal agent, strongly inhibits HBV replication in cells and in mice by blocking HBV capsid assembly. The crystal structure of the HBV core protein and ciclopirox complex reveals a unique binding mode at dimer-dimer interfaces. Ciclopirox synergizes with nucleoside/nucleotide analogs to prevent HBV replication in cells and in a humanized liver mouse model. Therefore, orally-administered ciclopirox may provide a novel opportunity to combat chronic HBV infection by blocking HBV capsid assembly.

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2020-01-08 16:01
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