[EZ-Cytox] Proteogenomic Characterization of Human Early-Onset Gastric Cancer
- - 짧은주소 : http://dogenbio.com/bbs/?t=99
- - 년도 : 2019
- - 제품명 : EZ-Cytox
- - 학술지명 : Cancer cell
- - 주소링크 : https://www.sciencedirect.com/science/article/abs/pii/S153561081830574…
We report proteogenomic analysis of diffuse gastric cancers (GCs) in young populations. Phosphoproteome data elucidated signaling pathways associated with somatic mutations based on mutation-phosphorylation correlations. Moreover, correlations between mRNA and protein abundances provided potential oncogenes and tumor suppressors associated with patient survival. Furthermore, integrated clustering of mRNA, protein, phosphorylation, and N-glycosylation data identified four subtypes of diffuse GCs. Distinguishing these subtypes was possible by proteomic data. Four subtypes were associated with proliferation, immune response, metabolism, and invasion, respectively; and associations of the subtypes with immune- and invasion-related pathways were identified mainly by phosphorylation and N-glycosylation data. Therefore, our proteogenomic analysis provides additional information beyond genomic analyses, which can improve understanding of cancer biology and patient stratification in diffuse GCs.