The Long Noncoding RNA HOTTIP Is Highly Expressed in Colorectal Cancer and enhances cell proliferation and invasion > REFERENCE LIBRARY

본문 바로가기
커뮤니티

[EZ-Cytox] The Long Noncoding RNA HOTTIP Is Highly Expressed in Colorectal Cancer and enhances cell proliferati…

김상진
2020-01-08 15:29 6,301 1

본문

년도
2019
제품명
EZ-Cytox
학술지명
Molecular Therapy-Nucleic Acids

Long non-coding RNAs (lncRNAs) are associated with a spectrum of biological processes such as gene regulation on transcriptional and post-transcriptional levels. The HOXA transcript at the distal tip (HOTTIP) lncRNA plays an important role in carcinogenesis, however, the underlying role of HOTTIP in colorectal carcinoma (CRC) remain unknown. The aim of the present study was to evaluate the expression and function of HOTTIP in CRC. In the present study, we analyzed HOTTIP expression levels of CRC patients in tumor and adjacent normal tissue by real-time quantitative PCR. Knockdown of HOTTIP by RNA interference was performed to explore its roles in cell proliferation, migration and invasion. Our results found that HOTTIP was up-regulated in human primary CRC tissues. Knockdown of HOTTIP inhibited CRC cell proliferation, migration and invasion. Above all, knockdown of HOTTIP could represent a rational therapeutic strategy for CRC.

댓글목록1

김상진님의 댓글

김상진
2020-01-08 15:29
카카오톡
이메일
견적/제품문의
샘플신청
게시판 전체검색