Enhanced anti-tumor immunotherapy by dissolving microneedle patch loaded ovalbumin > REFERENCE LIBRARY

본문 바로가기
커뮤니티

[EZ-LDH] Enhanced anti-tumor immunotherapy by dissolving microneedle patch loaded ovalbumin

김지현
2020-01-07 16:38 5,816 0

본문

년도
2019
제품명
EZ-LDH
학술지명
PLoS One

Abstract

The skin is a very suitable organ for the induction of immune responses to vaccine antigens. Antigen delivery systems to the skin by needle and syringe directly deposit the antigen into the epidermal-dermal compartment, one of the most immunocompetent sites due to the presence of professional antigen-presenting cells aimed at the induction of antigen-specific T cells. In this study, we analyzed the amount of ovalbumin as an antigen delivered to the skin by a microneedle. When ovalbumin protein as an antigen was delivered to the skin of mice using a dissolving microneedle, it induced an immune response through the enhanced proliferation and cytokines production by the splenocytes and lymph nodes. Also, it effectively increased the ovalbumin-specific CD8+ T cell and CD4+ T cell population and induced an ovalbumin-specific CTL response against the graft of ovalbumin-expressing EG7 tumor cells in the immunized mice. Also, we identified the inhibition of tumor growth and prevention of tumor formation in the context of the therapeutic and prophylactic vaccine, respectively through EG-7 tumor mouse model. Finally, these data show the potential of patches as attractive antigen delivery vehicles.

댓글목록0

등록된 댓글이 없습니다.
카카오톡
이메일
견적/제품문의
샘플신청
게시판 전체검색