Exosomal miR-193a and let-7g accelerate cancer progression on primary colorectal cancer and paired peritoneal metastatic cancer > REFERENCE LIBRARY

본문 바로가기
커뮤니티

[EZ-Cytox] Exosomal miR-193a and let-7g accelerate cancer progression on primary colorectal cancer and paired p…

김상진
2022-01-28 08:05 2,396 1

본문

년도
2021
제품명
EZ-Cytox
학술지명
Translational Oncology

Highlights

Exosomal miRNAs were derived from cancer cell lines and patient's blood.

Exosomal miR-193a was increased in peritoneal metastasis of colorectal cancer.

Exosomal let-7g was decreased in peritoneal metastasis of colorectal cancer.

Decreased miR-193a and increased let-7g were seen as cancer progression indicator.

Decreased miR-193a and increased let-7g were involved in patient survival rate.

Abstract

A metastasis of colorectal cancer is difficult to diagnose, and has a poor prognosis. Therefore, we tried to elucidate the possibility of a diagnostic and prognostic marker. Exosomal miR-193a and let-7g were sorted by miRNA microarray. The expression of miR-193a in the PTM group was lower than that of the primary CRC group, and the expression of let-7g was higher than that of the primary CRC. MMP16 and CDKN1A expression was confirmed respectively for target genes of two miRNAs. When the mimics of these miRNAs were treated with cell lines, both MMP16 and CDKN1A decreased intracellular expression. Cell invasiveness and proliferation were decreased by miR-193a and increased by let-7g. The differences in expression of exosomal miR-193a and let-7g extracted from the plasma of patients were classified as cancer progression indicators. Furthermore, the survival rate decreased in the group with low miR-193a expression and high let-7g expression. Our study confirmed the possibility of using this as a diagnostic and prognostic marker for colorectal cancer by measuring the expression levels of exosomal miR-193a and let-7g in blood.

댓글목록1

김상진님의 댓글

김상진
2022-01-28 08:06
JournalImpactFactor(2019) : 3.558
카카오톡
이메일
견적/제품문의
샘플신청
게시판 전체검색