[EZ-Cytox] Ciclopirox inhibits Hepatitis B Virus secretion by blocking capsid assembly
- - 짧은주소 : http://dogenbio.com/bbs/?t=9h
- - 년도 : 2019
- - 제품명 : EZ-Cytox
- - 학술지명 : Nature communications
- - 주소링크 : https://www.nature.com/articles/s41467-019-10200-5
Chronic hepatitis B virus (HBV) infection can cause cirrhosis and hepatocellular carcinoma and is therefore a serious public health problem. Infected patients are currently treated with nucleoside/nucleotide analogs and interferon α, but this approach is not curative. Here, we screen 978 FDA-approved compounds for their ability to inhibit HBV replication in HBV-expressing HepG2.2.15 cells. We find that ciclopirox, a synthetic antifungal agent, strongly inhibits HBV replication in cells and in mice by blocking HBV capsid assembly. The crystal structure of the HBV core protein and ciclopirox complex reveals a unique binding mode at dimer-dimer interfaces. Ciclopirox synergizes with nucleoside/nucleotide analogs to prevent HBV replication in cells and in a humanized liver mouse model. Therefore, orally-administered ciclopirox may provide a novel opportunity to combat chronic HBV infection by blocking HBV capsid assembly.